The ligand that binds to a receptor of a ligand gated ion channel does not bind

Question

The ligand that binds to a receptor of a ligand gated ion channel does not bind via covalent bonds. The best explanation for this phenomenon is: A) Covalent bonds are difficult to break, therefore once a ligand binds to the channel receptor to open it, it would be hard to close it again. B) Covalent bonds are not found in cellular proteins. C) Covalent bonds are mainly found in primary structures of proteins and not necessarily in protein-protein interactions. D) Covalent bonds may be polar, which will interfere with the specificity of channel. E) Covalent bonds may be hydrophobic which can interfere with die specificity of the proton.

Explanation / Answer

The best answer for a question 28 answers A as the explanation goes this way: covalent bonds are difficult to break, therefore once a ligand binds to the receptor to open it would be hard to close again. The reason for protein -ligand interactions are on and off so the signal transduction can be smooth otherwise the tight binding or covalent bonds can not result in proper signal movement across different strata.

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