Consider the impact of each substance on cellular respiration. Each substance ba
ID: 93641 • Letter: C
Question
Consider the impact of each substance on cellular respiration. Each substance bas an influence at the cellular level, and has no effect on hunger. Assume that the substances have no other impact on the cell other than the one described. 1. Substance's Effect: Impedes the binding of NAD^+ to electrons. Facilitator: _____ Classification: Potentially effective in promoting (circle one): Weight Loss Weight Gain Explanation for effect 2. Substance's Effect: Makes the lipid bilayer of the inner mitochondrial membrane highly permeable to (H^+) protons. Facilitator: _____ Classification: Potentially effective in promoting (circle one): Weight Loss Weight Gain Explanation for effect:Explanation / Answer
1) Substance impedes the binding of NAD+ to electrons
The substance results in weight loss.
Explanation: When the substanceblocks the binding of NAD+ to electrons, uncoupling of electron transport in electron transfer system occurs. This uncoupling of electron transport from ATP synthesis allows rapid oxidation of Krebs substrates, promoting the mobilization of carbohydrates and fats, since regulatory pathways are programmed to maintain concentrations of those substrates at set levels. Since the energy is lost as heat, biosynthesis is not promoted, and weight loss occurs.
2) Substance effect: makes the lipid bilayer of inner mitochondrial membrane highly permeable to H+ ions.
The substance causes weight loss.
Explanation: ATP is produced in inner mitochondrial membrane by maintaining electro-chemical gradient. When the inner mitochondrial membrane is permeable to H+ ion, electochemical gradient is lost and so ATP is not produced. This results in mobilization of carbohydrates and fats, since regulatory pathways are programmed to maintain concentrations of those substrates at set levels. Since the energy is lost as heat, biosynthesis is not promoted, and weight loss occurs.