Cholera is a dangerous disease caused by a bacterium, Vibrio cholerae, which sec
ID: 97637 • Letter: C
Question
Cholera is a dangerous disease caused by a bacterium, Vibrio cholerae, which secretes a toxin. This toxin has all of the following properties except Cholera toxin cleaves ATP and transfers the rbose-5-phosphate groups to other proteins Cholera toxin ADP-ribosylates the G_ alpha s subunit of heterotrimeric G proteins, thereby inhibiting their GTPase activity Cholera toxin increases the concentration of cAMP and activation of protein kinase A An overactive Protein kinase A phosphorylates the CFTR (cystic fibrosis transmembrane conductance regulator) chloride channel so that it remains permanently openExplanation / Answer
The vibrio cholerae toxin have all the properties except this property that cholerae toxin cleavage ATP and transfer the ribose-5-phosphate group to other proteins.
Instead ot cleavage ATP, cholerae toxin triggers indocytosis through the pentameric GM1 ganglioside receptor on the intestine cell.