please answer questions 2-5 Below is a diagram showing the inheritance of an X-l
ID: 98016 • Letter: P
Question
please answer questions 2-5 Below is a diagram showing the inheritance of an X-linked trait: the first generation is at the top and the third generation is at the bottom. Describe what this pedigree depicts in terms of gender, presence or absence of the disorder, and what feature(s) indicate that the pedigree is for an X-linked trait. In one experiment, Mendel crossed a pea plant that bred true for green pods with one that bred true for yellow pods. All of the F1 plants had green pods. What does it mean when an organism like Mendel's pea plants is true breeding? Which form of the trait (green or yellow pods) is dominant? Explain how you arrived at your conclusion. This should include the possible genotypes of the parents involved in the cross and those of the F1 generation. What type of mutation has occurred in the DNA of people with sickle cell anemia? (Look back, if you need to, to see what causes sickle cell.) A man who has type B blood and a woman who has type A blood could have children of which phenotypes? Explain your answer: be sure to consider what the possible genotypes are for both parents in your answer.Explanation / Answer
4) The sickle cell anemia is a genetic disease charecterized by severe anemia with major symptoms like muscle cramps, pallor, susceptibility to fatigue etc. In this disease, the red blood cells become sickle shape which has just a half shelf life of normal red blood cells leads to the premature death. The disease is caused by point mutation,that is an altration of a single nucleotide base within the DNA coding for the beta hemoglobin polypeptide. From the sixth DNA triplet CTC, the T (Thymine) is replaced with A( adinine ) and become CAC. As a result the sixth amino acid glutamate changed to Valine. This valine forms a hydrophobic association with nearby Valine in the first position which leads to the formation of abnormal hemoglobin molecule (hemoglobin S) which is less soluble in water than Hemoglobin S.