Consider the hypothetical serene protease below. Question 7 of7 Map sapling lear
ID: 982282 • Letter: C
Question
Consider the hypothetical serene protease below.
Question 7 of7 Map sapling learning onsider the hypothetical serine protease below, which shows the specificity pockets. The S1 pocket has a glutamic acid in the bottom, the S2 pocket is small and hydrophobic, and the S1 pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave S1 Which of the following sequences would this protease cleave? O Val-Leu-Lys O Lys-Leu-Val O Val-Lys-Leu O Leu-Lys-Val O Leu-Val-Lys O Lys-Val-Leu Previous Give Up & View Solution O Check Answer xt Exit HintExplanation / Answer
Solution.
The S2 pocket is small and hydrophobic. Valine is the smallest and the most hydrophobic among Val, Lys, Leu; so, the first is Val.
The S1 pocket has a negative charge,and will interact with a positively charged aminoacid, which is Lysine - it has long positively charged tail and has 2 aminogroups;
The S1' pocket need a bulky hydrophobic side chain - Leucine.
Answer: Val-Lys-Leu.