Please help! I think 72 might be E and I am not sure about the other two! Thanks

Question

Please help! I think 72 might be E and I am not sure about the other two! Thanks!!

72. Binding of agonists to protein membrane receptors can result in which of the following events? A. Conformational changes B. Intracellular release GDP C. Intracellular activation of kinase activity D. Intracellular formation of cGMP and/or cAMP E. All of these events can occur upon agonist binding. Several prostaglandin derivatives were synthesized in the lab and tested for their ability to sensitize a prostaglandin-specific G-protein coupled receptor and modulate cholesterol metabolism. According to the information below, which of the prostaglandin derivatives (PD) would form the most stable complex with the receptor? 73. A. PD1, Ko 1 nM C. PDI, KM = 1 nM 74. In the cAMP-dependent activation of pyruvate kinase, which of the following amino acids is phosphorylated? A. His B. Thr C. Tyr D. Ser E. Lys

Explanation / Answer

72)

Answer is E

Reason : An agonist is a chemicalcompound which binds to a receptor, activating the receptor to produce a biological response.

The response upon binding of an agonist to the cell membrane receptors activates one or more signal transduction systems, which initiate a cascades of different events which may change alter the concentration of intracellular second messengers, such as cAMP or Ca2+,and the signals are then transduced to the cytoplasm and then to the nucleus through a combination of second-messenger molecules, kinase/phosphorylation cascades, and transcription factor translocation to effect changes in genetic expression and protein translations.

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