The mechanism of action for -lactam (b-lactam) antibiotics including penicillin

Question

The mechanism of action for -lactam (b-lactam) antibiotics including penicillin is based on 1. Activation by cytochrome P450 2. It's mimicry of the peptide bond 3. Prodrug activation by esterases 4. Reduction by nitro reductase 5. Rapid non-enzymatic hydrolysis of beta-lactam ring The mechanism of action for -lactam (b-lactam) antibiotics including penicillin is based on 1. Activation by cytochrome P450 2. It's mimicry of the peptide bond 3. Prodrug activation by esterases 4. Reduction by nitro reductase 5. Rapid non-enzymatic hydrolysis of beta-lactam ring 1. Activation by cytochrome P450 2. It's mimicry of the peptide bond 3. Prodrug activation by esterases 4. Reduction by nitro reductase 5. Rapid non-enzymatic hydrolysis of beta-lactam ring

Explanation / Answer

Beta lactum rings in antibiotics inhibit the growth of bacteria cell wall. Beta lactum is a four membered ring and it has more strain. So, it readily react with cell wall of bacteria. The answer is option 5.

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