CLASSROOM RESPONSE QUESTION A patient with new prescriptionfor a p@-COA(statin)

Question

CLASSROOM RESPONSE QUESTION A patient with new prescriptionfor a p@-COA(statin) drug is instructed to take the medication with the evening meal or at bedtime The patient asks why it must be taken at this time of day The reason is A. The medication is better absorbed at this time. B. This timeframe correlates better with the natural diurnal rhythm of cholesterol production. C. There will be fewer adverse effects if taken at night instead of with the morning meal. D. This timing reduces the incidence of myopathy CLASSROOM RESPONSE QUESTION Which patient would beneáit from adminiarasion of simastain (Zocor) 80 mg A A patient newly diagnosed with hyperlipidemia B. A patient with muscle aches who was taking another antilipidenic drug C. A patient who is taking verapamil D. A patient who has already been taking simvastatin (Zocor) for 12 months with no evidence of myopathy

Explanation / Answer

Ans 1 B) This timeframe correlates better with the natural diurnal rhythm of cholesterol production.

Statins are HMG CoA reductase inhibitors which are useful in cardiovascular diseases as they lower the lipid levels in the body. Since most of the cholesterol is produced post evening in our body , the administration of statins will be most effective during this time.

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