Identify signs and symptoms of hepatotoxicity. Identify signs and symptoms of ne
ID: 138549 • Letter: I
Question
Identify signs and symptoms of hepatotoxicity. Identify signs and symptoms of nephrotoxicity. 1. What is the difference between potentiation and synergism? 2. Before administering lovastatin, a potentially hepatotoxic lipid-lowering medication, the nurse reviews the patient's laboratory tests. Test results include alanine aminotransferase (ALT) 334 (0-35) and aspartate aminotransferase (AST) 197 (0-35). The nurse should: a. administer the medication. b. assess the vital signs before administering the medication. c. hold the medication and report the results to the prescriber. d. notify the prescriber STAT. The nurse is teaching the patient who has been prescribed terbinafine tablets 250 mg once a day for 12 weeks for toenail onychomycosis. Because the drug can be hepatotoxic, the nurse teaches the patient to report: (Choose all that apply) a. Constipation 73. b. Light-colored stool c. Rash d. Yellow-colored skin e. Pale conjunctiva f. Anorexia g. Angioedema h. Nausea and vomiting i. Tarry stool 74. A patient who is prescribed a medication for degenerative joint disease experiences edema and shortness of breath (SOB) within 24 hours after a new medication is started Drug information does not include these symptoms as adverse effects. The medication is discontinued, and the edema and SOB disappear, but the joint symptoms return. The prescriber restarts the medication, and the edema and SOB occur again. The nurse should: a. b. admin administer the medication because edema and SOB are known adverse effects. ister the medication because it has been prescribed by the prescriber. report the event to www.fda gov/medwatch hold all medications until the cause of the edema and SOB are identified. d.Explanation / Answer
Sign of hepatotoxicity is
Dark color urin
Jaundice (yellowish discoloration of skin and mucous membrane)
Anorexia
Stomach pain
Tiredness
Light color bowel movement
LFT shows elevated liver enzymes
Sign of nephrotoxicity
Decrease urin output
Sign of fluid retention edema and shortness of breathing
Confusion
Nause and vomiting
KFT shows elevated s creatnine and BUN
there is difference between potentiation and synergism
Potentiation is action of single medication or salt
And synergism is two or more anti-infective agents given together that is greater then the sum of activity had the agent been given separetely
Lovastatin is lipid lowering hepatoxic drug if ordered with elevated SGOT AND SGPT -hold the medication and report to health care providers
Terbinafine is also have hepatoxic effect which shows
Light stool color
Yellow skin color anorexia
Nausea and vomiting
In question 74 these are the sign of fluid retention and are the adverse effect of drugs are expected drugs can continuous