Imagine that you are part of a research team that specializes in diagnosing diso
ID: 148661 • Letter: I
Question
Imagine that you are part of a research team that specializes in diagnosing disorders associated with malfunctioning cellular organelles and structures. Doctors consult your group to help diagnose particularly difficult cases. For the cases below, determine which organelle is defective based on patient history, physical examination, laboratory results. Provide rational for your diagnosis. You may use your textbook, lecture notes, intemet, or other resources in this part. Case #1 ld male with fatigue, muscle weakness, low endurance, loss of coordination, and progressive difficulty walking Physical Examination: Muscle loss & deformity; Awkward gait; Difficulty breathing Laboratory Results, Cells have abnormal shape, Cell division is abnormal: Impaired Diagnosis Malfunctioning Organelle: j o sis (exsplanation of how history,physical examination and laboratory results suggest diagnosis)
Explanation / Answer
Answer:
Diagnosis:
1. Malfunctioning organelle is Microfilaments.
2. Rationale for diagnosis: As microfilaments are main component of cytoskeleton which maintain shape of the shape of cell and also responsible for the movement of materials inside the cell. These are account for the proper cell division, as these are the component of spindle (form during cell division). Microfilament, actin and myosin involve in muscle contaction.
Hence, defective microfilament causes abnormal shape of cells, abnormal cell division and impaired movement of cellular materials. This leads to muscle deformity, loss and muscle functionality.