Match the words (A-E) with the statements below: ( 10 pts) A. Bohr B. 2, 3-BPG C
ID: 149167 • Letter: M
Question
Match the words (A-E) with the statements below: ( 10 pts)
A. Bohr
B. 2, 3-BPG
C. Carbamate
D. Carbon dioxide
E. Concerted
F. Distal Histidine
G. Heme
H. Hemoglobin
I. Myoglobin
J. Sickle Cell Anemia
This has the ability to protect against carbon monoxide binding to the heme _______________
This is the molecule whose function is to facilitate diffusion of oxygen in muscle cells. ___________
The ability of myoglobin to bind oxygen depends on the presence of a bound prosthetic group called .
The shape of this protein has a sigmoidal curve _______________
As the partial pressure of ___________ increases, the affinity of oxygen binding to hemoglobin decreases. (there can be two answers)
The effect of hydrogen ions and carbon dioxide on the binding of oxygen to hemoglobin is called the _____________ effect
___________ is an allosteric effector that binds to the positive charges on the hemoglobin molecule .
Hemoglobin binding of oxygen is best described as a combination of sequential and ______________ model.
Carbon dioxide forms ______________ groups in proteins by reaction with N-terminal groups.
This condition is a result of a single-point mutation in the chain of hemoglobin:__________________
Explanation / Answer
1. Distal Histidine has the ability to protect against carbon monoxide and alkyl isocyanides binding to the heme.
2. Myoglobin is the molecule whose function is to facilitate diffusion of oxygen in muscle cells.
3. The ability of myoglobin to bind oxygen depends on the presence of a bound prosthetic group called Heme.
4 The shape of this protein has a sigmoidal curve ______________ _, this question should be like, the shape of affinity curve for which molecule is sigmoid? the answer is hemoglobin.
5. As the partial pressure of CO2 increases, the affinity of oxygen binding to hemoglobin decreases. this is known as the Bohr effect ( answer for 6th)
7 2, 3-BPG is an allosteric effector that binds to the positive charges on the hemoglobin molecule. ( 2,3-BPG binds to deoxyhemoglobin, it acts to stabilize the low oxygen affinity state (T state) of the oxygen carrier)
8. Hemoglobin binding of oxygen is best described as a combination of the sequential and Concerted model.
9. Carbon dioxide forms Carbamate groups in proteins by reaction with N-terminal groups. The N-terminal amino groups of valine residues in the - and -chains of deoxyhemoglobin exist as carbamates. They help to stabilize the protein.
10. The condition which is the result of a single-point mutation in the chain of hemoglobin: Sickle Cell Anemia. at 6th position, valine replaced glutamic acid (GAG to GTG).