Consider cargo proteins that are destined for secretion to the extracellular spa
ID: 163254 • Letter: C
Question
Consider cargo proteins that are destined for secretion to the extracellular space.
For each of the following pairs of mutations or conditions, predict where the cargo
will end up (ex. in the cytoplasm, a specific organelle, transport vesicles, multiple
places, extracellular space) for: (i) & (ii) Each individual condition; & (iii) The
combination of both.
(i) COPII coat proteins are mutated so they don’t bind to the ER membrane.
(ii) COPI coat proteins are mutated so they don’t bind to the Golgi membrane.
(iii) Both
Explanation / Answer
i. From the Rough Endoplasmic Reticulum to the Golgi Complex
2.Transports the protein back from the cis end of the Golgi complex to the rough Endoplasmic Reticulum.
3-interface of the ER-Golgi complex.