Queen Victoria\'s youngest child, Beatrice (IV-12) introduced the hemophilia all
ID: 168754 • Letter: Q
Question
Queen Victoria's youngest child, Beatrice (IV-12) introduced the hemophilia allele to the Spanish royal house. She married Henry who did not have a history of hemophilia in his family. Beatrice and Henry had 4 children; 1 unaffected son, 1 unaffected daughter (Eugenie), and two sons with hemophilia. Eugenie married King Alfonso XIII of Spain. They had 6 children, including two sons with hemophilia and two unaffected sons. The present day king of Spain, Juan Carios (VII-4), does not have hemophilia and is a son of one of Eugenie's unaffected sons. What is the most probable genotype of Beatrice? X(H)X(h) X(H)Y X(h)X(h) X(H)X(H) X(h)Y What is the most probable genotype of Eugenie? X(h)Y X(H)X(H) X(H)Y X(H)X(h) X(h)X(h) What is the genotype of King Juan Carios? X(H)X(h) X(H)Y X(h)YExplanation / Answer
1) Beatrice is a carrier of the disease and so her genotype :
X(H)X(h)
2) Eugenie is also a carrier
X(H)X(h)
3) Carlos is unaffected so his genotype is
X(H)Y