For scientists who are trying to construct a genetically modified animal strain,
ID: 175272 • Letter: F
Question
For scientists who are trying to construct a genetically modified animal strain, germline integration is a major concern. Why?
a. Random transgene insertions can mutate an endogenous gene. b. Genetically modified foods have unpredictable health risks. c. Germ cells have heterochromatin, which can silence transgene transcription. d. Germline integration is required for the transgene to become part of the host cell’s genome. e. Germline integration is required for the genetic modification be passed along to offspring.Explanation / Answer
Germline integration would prove to be a success when the integrated gene of interest shows its expression. And as per the name, it gets into the germline, which means that the modification in the genome should be able to be showcased in the off spring. Therefore,scientists trying to construct a genetically modified animal strain, find germline integration is a major concern as germline integration is required for the genetic modification be passed along to offspring.