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Assume that you are studying an esterase gene in population ofDrosophilaand you

ID: 197455 • Letter: A

Question

Assume that you are studying an esterase gene in population ofDrosophilaand you getthe allozyme gel below. Calculate genotype and allele frequencies for this sample. Is thepopulation in Hardy-Weinberg equilibrium? Calculate the2test statistic and provide ap-valueto accompany your answer. Calculate the heterozygosity and homozygosity of this locus. Notethat the thin lines are gel loading wells, not allozymes for this gene.

you are studying an esterase gene in population of Droso below. Calculate genotype and allele frequencies for th -Weinberg equilibrium? Calculate the X2 test statistic an ur answer. Calculate the heterozygosity and homozygosity s are gel loading wells, not allozymes of the gene. dy uria is an autosomal vecossive fo

Explanation / Answer

Here AA=11

AB =13

BB = 5

Total genotypes: 29

Total alleles: 58

Total A allele = 22 + 13 = 35

Total B allele = 10+13= 23

Frequency of A (p) = 35 / 58 = 0.60

Frequency of B (q) = 1 - p = 0.39


p allele freq = 0.64; q allele freq = 0.36

Solutions for perfect HWE, under a model of ascertainment (+/-) of one group

Genotype Expected Observed Common homozygotes 11.8 13 Heterozygotes 13.4 11 Rare homozygotes 3.8 5