In the context of DNA sequencing, what is a reference genome? A series of locati
ID: 199200 • Letter: I
Question
In the context of DNA sequencing, what is a reference genome?
A series of locations of anchor genes, notated in centi-Morgans. The sequence reads are then randomly placed between these anchor genes, and the likelihood of the random placement being the actual order is calculated.
A representative example of a species' set of genes, to which segment reads are aligned by bioinformatics software.
Much like a reference encyclopedia, a reference genome is a book on a library shelf, but instead of words it contains the entire sequence of a genome. It also has one-page descriptions of genes. So when you are doing a sequence project, you use this as a reference to check if your sequence fragment is contained within a gene.
A database of all the known possible types and locations of mutations along an entire genome. It is very useful when you are doing sequencing, as you can compare it to what is already discovered, and thus determine if you have found a yet-undiscovered variant.
A series of locations of anchor genes, notated in centi-Morgans. The sequence reads are then randomly placed between these anchor genes, and the likelihood of the random placement being the actual order is calculated.
A representative example of a species' set of genes, to which segment reads are aligned by bioinformatics software.
Much like a reference encyclopedia, a reference genome is a book on a library shelf, but instead of words it contains the entire sequence of a genome. It also has one-page descriptions of genes. So when you are doing a sequence project, you use this as a reference to check if your sequence fragment is contained within a gene.
A database of all the known possible types and locations of mutations along an entire genome. It is very useful when you are doing sequencing, as you can compare it to what is already discovered, and thus determine if you have found a yet-undiscovered variant.
Explanation / Answer
A reference genome can be described as:
A representative example of a species' set of genes, to which segment reads are aligned by bioinformatics software.