Please answer the following questions for numbers 21, 22,23 and 24 please! If yo

Question

Please answer the following questions for numbers 21, 22,23 and 24 please! If you are not sure please write it next to the problem number. I am a little confused on these, I will rate good!

21-23. The following lists structures found in voltage-gated Na channels: A) Negative charges in each transmembrane domain B) The P-loop between helices 5 and 6 of each domain C) The cytoplasmic loop between domains Ill and IV D) Positive charges in the 4th segment of each domairn Which one confers the following functional properties? 21. Voltage-sensitivity? 22. lon selectivity? 23. Inactivation? 24. Initiation of the action potential usually occurs of the neuron. a. in the cell body b. on the dendrites c. at the synapse d. on the axon e. at the axon initial segment

Explanation / Answer

21. Voltage sensitivity comes from the S1-S4 segment.

22. Ion-selectivity comes from the P-loop between S5-S6 segment

23. Inactivation is done by the cytoplasmic loop between domain III and IV

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