The Case: Mystery of the Toxic Flea Dip You\'re working at the medical examiner\
ID: 202494 • Letter: T
Question
The Case: Mystery of the Toxic Flea Dip You're working at the medical examiner's office at San Francisco County Hospital. It has been a particularly light day, with only 1 homicide and a dead chipmunk that you checked over for rabies. The chipmunk didn't have rabies, and you're ready to go home. Just as you're flipping the switch, you get a call from your secretary. "Francesca," he says. "We've got a dead kid up here that you'll want to look at right away. Might be foul play." Thinking of your four-year old daughter waiting for you at home, you grimace. "OK Jon, I'm heading to the morgue." Performing autopsies on kids is the least favorite part of your job. But you are paid to solve medical mysteries, and it looks like you've got one here. In the morgue, you find the report from the hospital. Glancing over it, you notice a narrative of the girl's last hours and read it carefully: At 10 AM, mother returns from the store to find girl vomiting, not feeling well, and sleepy. Mother put girl to bed. Ten minutes later, she noticed that the child's breathing became irregular and slow. She tried to wake her daughter but was not able to do so. The child became comatose. At noon, the girl was admitted to the hospital, with no heartbeat or spontaneous breathing. A police report states the following: The parents discovered that the girl had been giving her dog a bath using a flea dip called Fleacide. According to the label on the container, Fleacide is an insecticide made of plant material only and appropriate for external use on animals. It contain rotenone, which is known to be toxic in high levels. DADT 1. The Clea ninExplanation / Answer
IMAGE 1 IS NOT APPEAR FULLY SO I WILL START ANSWERING WITH QUESTION 3
Q 3-What cellular process was impaired by the Fleacide?
Ans 3-the acetyl coenzyme A level was normal that show that glycolysis was performed normally. But ATP are absent in mitochondria that suggest that either citric acid cycle or Electron transport chain was impaired.
Ans 4-The decreased level of NAD+ and the increased level of NADH show that the first step of electron transport chain was disrupt. specially, the NADH dehydrogenase function, that convert electron carrier i.e. NADH, to NAD+, was blocke by the Fleacide.
Ans 5-there is no any possibility. The decreased level of NAD+ of heart cells was just a indication of the poisoning. The real cause was that prevention of the transfer of electrons by rotenone from NADH to the electron transport chain throgh inactivated NADH dehydrogenase. So, adding NAD+ to the cell can finally help increased the collection of NADH, but this would not restore the electron transport chain’s function.
Ans 6- there is no any possibility. The cause is that the transfer of electrons prevented by rotenone from NADH to the electron transport chain through inactivat NADH dehydrogenase. The increased concentration of oxygen do not solve fault in the electron transport chain.