Partl-Haplotypes \"You know, Karen, something very unusual has happened Because
ID: 209359 • Letter: P
Question
Partl-Haplotypes "You know, Karen, something very unusual has happened Because a transplanted organ is seen as foreign tissue to here. Weve tested your sons because they were possible donors.a host's immune system, it is important to try to "match Your sons' blood does not match your blood and that's anup" as many impossibility, so they couldnt be your children...these couldrejection of the new organ. The chance of matching is not be your children. Karen's hand shook as she listened to the nurse on the telephone tell her that two of her three sons could not possibly be hers. Karen, who was 52 years old, was in need of these genes as possible to minimize the highest among related individuals. The nurse told Karen that her lab report results indicated that her HLA haplotype is type 1 and 3 and her three sons of a kidney transplant. She and her sons had undergone erepes 2 and f, 2 and s. and i and 6, respectively blood tests to determine if they were suitable donors. The tests determedthei human leukocyte antigen (HLA) Questions genes, some of which encode cell surface r proteins that the body uses to distinguish its own cells from foreign material. Because there are hundreds of different versions of the z00+ HLA genes, each person's 2. According to these data, which sons cannot be hers? combination is almost unique. However, because these genes are located in a group on chromosome #6, they are 3, What are some hypotheses to explain these data? Write often inherited together in a block known as a haplotype (see Figure 1) ecognition1. How many HLA haplotypes should this woman's sons each share with her? down as many explanations as you can, no matter how far-fetched. Figure 1. Location of HLA genes. 4. What tests should be done next to evaluate your hypotheses? HLA genes chromosome #6Explanation / Answer
Answer 1: Atleast one of the HLA haplotype should be shared by woman,s son with her becuase the son recieves the one set of chormosome from the both parents ie one from mother and one from father.Like in this case the woman HLA haplotype is type 1 and 3 which is shared by one of the son contains haplotypes type 1 and 6, this share the type 1 with the woman.
Answer 2: According to the data the two son with haplotypes type 2 and 5 are can not be hers because these son not share any haplotypes with her (mother haplotype is type 1 and 3).
Answer 3:The gene for the HLA antigen or haplotype is present on chromosome number 6 which is transfered to there childrens. The childrens obtained the one haploid set of chromosome from mother (egg) and one haploid set of chromosome from father (sperm), it clearly indicates that the childrens atleast have one set of HLA haplotypes matches with mother and one haplotype with father. If it is not matches confirm that childrens does not belong to those parents.
Answer 4: The hypothesis can be further confirmed by performing DNA fingerprinting, if the DNA fingerprint or DNA bands of sons does not matches with the mother it confirm that these sons are not her.