Patients with Common Variable Immune Deficiency (CVID, http://ghr.nlm.nih.gov/co
ID: 210772 • Letter: P
Question
Patients with Common Variable Immune Deficiency (CVID, http://ghr.nlm.nih.gov/condition/common-variable-immune-deficiency) all show reduced levels of serum IgG, IgA, and IgM. This leaves them susceptible to a wide range of bacterial and viral diseases, especially of mucus membranes.
Furthermore, 25% of CVID patients also suffer from an autoimmune disorder (AI), the most common of which are B cell-driven anti-erythrocyte or anti-platelet cytopenias.
Given what you know about B cell development and the activation of B cells, can you hypothesize a model that explains how serum antibody-low CVID patients can ALSO suffer a B cell-driven AI?
Would you expect to see a difference in a white blood cell count? What would you expect?
Then, identify 2 possible genes/proteins that might be responsible for combined CVID/AI, and describe how they could produce such a phenotype.
Explanation / Answer
Ans- in CVID the no of B cells vary from individual to individual or we can say that in some cases it increase while in some cases it decrease so low number CVID will effect in same manner as high CVID.
The white blood cells may be expected to decrease in CVID
The genes included in CVID are CD19 , ICOS , TACI . They produce such phenotypes by losting the property of identification of self or non self.