Please help me solve this pedigree (autosomal dominant/recessive) To better prio
ID: 210791 • Letter: P
Question
Please help me solve this pedigree (autosomal dominant/recessive)
To better prioritize your studying, below is the EXACT pedigree (only one will be given) that will be on Exam 2 Please know if the inheritance pattern is: a) autosomal dominant b) autosomal recessive c) sex-linked (X) recessive (ONLY 3 CHOICES WILL BE GIVEN) ALSO as discussed, be comfortable with .generating Punnett Squares to solve problems what should the phenotypes of complete dominant vs. codominant vs.incomplete dominant look like for AA, Aa, aa individuals? If heterozygotes (Aa) are mated to each other, what would the resulting phenotype ratios be for each of these 3 allele interaction categories? Genotype ratios?Explanation / Answer
Had the disease been autosomal recessive, then both the parents have 2 faulty copies of the allele and hence all of their progeny should have been affected, which is not the case here.
Had the disease been X-linked recessive, then all male offsprings off female affected mothers would be affected, as the father in this case only provides a Y-chromosome. Likewise, all females from male unaffected parents will remain unaffected. Both of these scenarios are not true for the first generation, hence not the case.
In case of autosomal dominant disease, even one copy of the allele is enought to produce a response, hence this justifies the proposition that both the parents were heterozygous carriers which is why only half their progeny wen on to show the disease in the first generation. Hence, it is autosomal dominant disease.