Please use these concentration for a \"typical\" mammalian neuron ons K* Na* cl
ID: 212712 • Letter: P
Question
Please use these concentration for a "typical" mammalian neuron ons K* Na* cl Ca2 Conc. Inside (mM) Conc. Outside (mM) 140 10 17 0.0001 145 110 Problems for "Typical" mammalian neuron 1. The table above summarizes the concentrations of 4 major ions in "typical" mammalian neurons. Calculate the equilibrium potentials for each of the ions. 2. Pretending that you are only interested in the contributions of Na+ and K+, calculate the membrane potential for a mammalian neuron during (1) resting (P:P 1:0.04), and during (2) peak AP (P: Psa 1:20).Explanation / Answer
The Nernst Equation is used in physiology to determine the electric potential of a cell membrane with respect to a single ion.
where
R = gas constant = 8.314472 J · K-1
T = temperature (Kelvin)
F = Faraday's constant = 9.65 x 104 C mol-1 At 37 °C,
Therefore, The equilibrium potential for the
Ion
K+ = - 89.2 mV
Na+ = 71.44 mV
Cl- = - 49.88 mV
Ca2+ = 132.28 mV
2. As per Goldman-Hodgkin-Katz equation
For pk:pNa (1:0.04) = -0.08064049436088977
For pk:pNa (1:020) = 0.05504866478561544