Student ID: BC403-001/230 Problem Set #3 Due: 3/26/2018 10 points Instructions:
ID: 214872 • Letter: S
Question
Student ID: BC403-001/230 Problem Set #3 Due: 3/26/2018 10 points Instructions: Please answer the following questions as fully as you can while being concise with student is expected to hand-in their own work and plagiarism is unacceptable and will result in a problems that require mathematical calculation your work must be shown to receive full credit. your answer. You may work together and use any and all resources available to you. Eaclh zero for the assignment. Multiple offenses will be met with more severe consequences. For 1. BeriBeri is a neurological and cardiovascular disease that is the result of thiamine deficiency. The disease can result in lactic acidosis and elevated -ketoglutarate levels in the blood. Interestingly both mercury and arsenite poisoning can lead to symptoms and blood work that mirror BeriBeri. Both mercury and arsenite have high reactivity for free sulfhydryls and form covalent bonds with them. Given this information explain how a thiamine deficiency or mercury/arsenite poisoning lead to lactic acidosis. A full answer will describe the mechanism of their (thiamine deficiency and mercury/arsenite poisoning) action. 5 points)Explanation / Answer
Thiamine is a water soluble vitamin. This is used in the metabolism of carbohydrates. Thiamine acts as a cofactor for several enzymes like pyruvates dehydrogenasse, which converts pyruvate to aceyl CoA in mitochondria. If thiamine is deficient in body, pyruvate is not able to entre the TCA cycle and instead gets converted into lactate. This lactate accumulates and leads to lactate acidosis.