The CFTR gene (remember this from a previous clinical connection?) contains the
ID: 215303 • Letter: T
Question
The CFTR gene (remember this from a previous clinical connection?) contains the sequence ATCATCTTTGGTGTT, which codes for residues 506-510 of the protein.
a.) Identify the residues in this segment of the protein.
Ans.) This segment has the sequence Ile-Ile-Phe-Gly-Val.
b.) In the most common mutated form of the gene, this same segment of DNA has the sequence ATCATTGGTGTT. What type of mutation has occurred and how does it affect the sequence of the encoded protein?
Ans.) The mutation is the deletion of three nucleotides (CTT), affecting codons 507 and 508. The resulting protein segment has the sequence Ile-Ile-Gly-Val, which is missing Phe 508.
c.) What type of mutation has occurred and how does it affect the sequence of the encoded protein?
Please check my work and help with the last question. Thank you!
Explanation / Answer
I think your answer is right.
The mutation is a deletion mutation where phe is deleted.