Forward genetic screens for gones that affect ethanol sensitivity identified poi

Question

Forward genetic screens for gones that affect ethanol sensitivity identified point mutations in the Drosophila Adh gene However, no point mutations were recovered that lie within the Adte gene This is most likely due to O A The Adh gene is more readily mutagenized than the Adhr gene O B. The Adh gene is more conserved over evolution than the Adhr gene O C The Adhr gene is more conserved over evolution than the Adh gone OD The Adh gone yields a phenotype when inactivated by mutation, the Advr gene does not OE The Adhr gone yiekds a phenotype when inactivaled by mutation, the Adh gene does not

Explanation / Answer

Answer: Option C is correct.

Explanation: During mutagenesis, all the loci have equal probabilities of acquiring mutations. However, mutations in evolutionarily conserved/essential genes can not be tolerated. So, such mutants die prematurely/embryonic or early life stages. Hence these mutants can not be isolated/maintained.

In the given case, mutations in ADHR locus could not be isolated indicating that it is an evolutionarily conserved essential gene.

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