A 62 year old man is initially seen in the Emergency Room complaining of difficu
ID: 242117 • Letter: A
Question
A 62 year old man is initially seen in the Emergency Room complaining of difficulty with speech and swallowing due to and enlarged tongue. Physical examination also reveals a large, sublingual hematoma. In addition, multiple ecchymoses of his skin are noted. He has no history of trauma nor has there been any pervious episodes of bleeding. Coagulation studies show:
Platelet Count: 180,000/cumm
PT: 12 sec
APPT: 72 sec
TCT or thrombin time: 10 sec
Fibrinogen: 225%
Additional laboratory studies reveal:
Normal plasma: 20% 50% 80%
Patient plasma 80% 50% 20%
Repeat APPT: 72 sec 70 sec 68 sec
1. What do the results of the mixing study indicate?
2. What is the most probable cause of this result?
Explanation / Answer
1.mixing study indicates the prolonged APTT Level.normal is 30 to 50 seconds.it is mainly due to heparin therapy or oral anticoagulant use.
2.it is due to factor VIII deficiency