III IVI VII VIII IX wild type) G460A Ala154Thr Tyr240Cys A719G TPMT*3B G460A Ala
ID: 255029 • Letter: I
Question
III IVI VII VIII IX wild type) G460A Ala154Thr Tyr240Cys A719G TPMT*3B G460A Ala154Thr TPMT"3C A719G Tyr240Cys TPMT parameter Wild type "3A allele *3B allele *3C allele Formation (fmol/ mg/hr) 335 268 349 220 Degradation t1/2 (hr) 18 0.25** 18 38. Which exon is the most important for the difference in degradation of enzyme for 3B? a. exon 7 b. exon 10 c. exon 5 d. both exon 7 and 10 are equally important e. none of the above 39. Tom has the 3 C phenotype. Ile would be a. need a lower dose of drug than Mary with the 3A phenotype. b. Need a greater dose of drug than Mary with the 3 A phenotype c. Need a greater dose of drug than Sarah with the 3 B phenotype d. Need a greater dose of drug than both Mary and Sarah e. Need a lower dose of drug than both Mary and SarahExplanation / Answer
38. According to the degradation data, 3A and 3B allele show significantly lower degradation time. So the mutation common to 3A and 3B allele is responsible for the difference. The mutation shared by both these alleles is in exon 7.
ANSWER: a. exon 7
39. According to the degration data, the time required for degrading half of the molecules are leeser in 3B and 3C phenotype than that in wildtype and 3C phenotype. That means, the 3B and 3C phenotypes degrade faster and therfore, they need higher dose than wildtype and 3C phenotype. In othe words, wildtype and 3C phenotype require lower dose than 3B and 3C phenotypes.
ANSWER: e. Need a lower doseof drug than both Mary and Sarah.