Microbiology: Virulence Fill in the following chart appropriately by listing 5 d

Question

Microbiology: Virulence

Fill in the following chart appropriately by listing 5 different pathogens.

To each pathogen fill/write the route of infection, disease(s), Virulence Factor (pili/adhesion), Pathogenicity Island, phage or plasmid, Exotoxin or Endotoxin, Secretion system, and Antibiotic (with mode of action)

Challenge Chart Pathogen Route of Disease(s) Virulence Factor Pathogenicity Exotoxin or Secretion Antibiotic infection (pili/adhesin) land, phageEndotoxin System (with or plasmid mode of action)

Explanation / Answer

Type I secretion system (T1SS)

Mannheimia haemolytica

PATHOGEN ROUTE OF INFECTION DISEASE VIRULENCE FACTOR PATHOGENICITY ICELAND, PHAGE OR PLASMID EXOTOXIN OR ENDOTOXIN SECRETION SYSTEM ANTIBIOTIC Escherichia coli food borne urinary tract infection P fimbriae pahage Shiga toxin(endotoxin)

Type I secretion system (T1SS)

rifampin- beta subunit of RNA polymerase during RNA synthesis Staphylococcus aureus contamination contact, bloodstream

• Osteomyelitis -inflammation of the bone marrow

surface associated proteins pahage exotoxins VII protein secretion system (T7SS) flucloxacillin- cell wall synthesis inhibition Bordetella pertussis whooping cough fimbriae and pertactin plasmis Pertussis toxin (PT)-exotoxin type III secretion system (T3SS) Azithromycin- inhibiting protein synthesis by binding with 50 s subunit

Mannheimia haemolytica

direct transmission via nasal secretions or droplets bovine pleuropneumonia leukotoxin (LKT)-exotoxin lateral gene transfer leukotoxin (LKT) type III secretion system danofloxacin-dna gyrase inhibition Clostridium butyricum food source Botulism enterotoxins plasmis exotoxin type III secretion system penicillin G-cell wall synthesis

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