Answer ALL questions please. ALL QUESTIONS NHA NH? NH2 glutamate dehydrogenase I
ID: 260453 • Letter: A
Question
Answer ALL questions please. ALL QUESTIONS
NHA NH? NH2 glutamate dehydrogenase I glutamine synthetase 2) Pyruvate dehydrogenase is allosterically COOH COOH H2 CH2 activated by fructose-1,6-bisphosphate, andH allosterically inhibited by NADH and acetyl- CoA. What does an increased level of NADH and acetyl-CoA indicate about the cell's physiological state (what is going on in the cell), why would pyruvate dehydrogenase be the point of regulation, and what is the fate of pyruvate (be specific) CH2 CH-NH2 COOH glutamine 0% C O NAD(P)H COOH NH2 ATP NAD(P)" COOH glutamate ADP, H3PO4 oketoglutarate CoA-SH COA NAD NADH acetyl CoA pyruvate CoExplanation / Answer
1-Levels of NADH and Acetyl Co-A tells about the metabolic state of a cell. Acetyl Co-A is also an indicator of the general energy state of a cell. Acetyl coenzyme A alters the activity of many enzymes either in an allosteric manner or by altering the substrate availiability . It acetylates a number of shbstrates including the histone proteins and many other and controls cellular metabolism , autophagy and mitosis.
2-Pyruvate dehydrogenase catalyses an irreversible reaction. The products ATP and NADH allosterically inhibhit the reaction. Therefore its a straightway link between a pathway and metabolic requirement it serves.
3- Pyruvate gets converted to Acetyl CoA and enters the citric acid cycle after getting converted by pyruvate dehydrogenases.