Individuals who express HLA-B27 are 90 times more likely to develop the autoimmu
ID: 266429 • Letter: I
Question
Individuals who express HLA-B27 are 90 times more likely to develop the autoimmune disorder ankylosing spondylitis than individuals with a different HLA allele at this locus; this leads to the conclusion that [complete the sentence and assess the resulting statements (46-49) as either factually correct (true) or incorrect (false)]:
46. HLA-B27 causes ankylosing spondylitis.
47. individuals with HLA-B27 are highly likely to develop ankylosing spondylitis.
48. autoimmune disorders must have genetic components.
49. most patients with ankylosing spondylitis express HLA-B27.
Explanation / Answer
This leads to the counclusion that autoimmune disorders have a genetic component.
Further :
46- False , its just associated with increased chances to develope the disease
47- False , it varies with the ethnic groups
48- True
49- True - > 95%