Please answer the following questions. 1. Biochemical signaling pathways interac
ID: 268811 • Letter: P
Question
Please answer the following questions.
1. Biochemical signaling pathways interact by sharing molecules, resulting in an integrated, coordinated response on several levels. What second messenger molecule propagates ? adrenergic receptor signaling and also regulates nuclear CRE-binding proteins by phosphorylation? A. 1,2-diacylglycerol B. cyclic AMP C. calcium D. inositol 1,4,5-trisphosphate E. NO 2. Which protein motif does NOT bind DNA? A. helix bundle B. zinc finger C. helix-turn-helix D. homeodomai?n E. All of these bind DNA 3. Hormone response elements are A. bound by the hormones alone B. physical regions in the testis that control testosterone production C. composed of two consensus sequences of six nucleotides, contiguous or separated, in tandemor palindromic. D. composed of GC rich regions in the 3' region of the gene E. bound by monomers of the hormone receptor complex 4. How does cAMP regulate transcription? A. cAMP activates PKA, which phosphorylates TBP B. cAMP binds CREB C. cAMP activates PKC, which phosphorylates CREB D. cAMP activates PKA, which phosphorylates CREB E. cAMP binds TBPExplanation / Answer
1.
B. Cyclic AMP . As both Cyclic AMP and 1 , 2 - diacyl glycerol are second messenger but Cyclic AMP only regulates CRE binding proteins which are cyclic AMP response element binding protein.
2.
E . All of these binds DNA. All protein motifs bind DNA .
3.
C. composed of two consensus sequences of six nucleotides , contiguous or separated in tandemor palindromic. The sequence is most commonly a pair of inverted repeats separated by three nucleotides.
4.
D.cAMP activates PKA ,which phosphorylates CREB.cAMP activates protein kinase A from it's inactive form which then activate phosphorylase b kinase .