Case Study #6 A 26-year-old woman presented with painful, stiff knees of 4 weeks
ID: 270716 • Letter: C
Question
Case Study #6 A 26-year-old woman presented with painful, stiff knees of 4 weeks duration. She had a 6-year history of Raynaud's phenomenon. On examination, she had bilateral effusions in both knee joints, but all other joints were normal. She had no skin lesions, muscle tenderness, proteinuria or fever. The results of relevant investigations are shown in Table C10.1. On the basis of these, a diagnosis of and the patient treated with aspirin for her painful knees. She improved over 4 weeks and then remained symptom-free for 5 years. During this time, her antinuclear antibody remained positive at 1/80, her DNA-binding activity varied from 40 to 80%, and her C3 and C4 levels were occasionally low. Later, she developed a bilateral, blotchy rash on her hands and thighs, consistent with active vasculitis. Her Raynaud's phenomenon concurrently became much worse. Following treatment with prednisolone, the skin manifestations gradually disappeared and the steroids were tailed off ?????was made This patient presented with arthritis and Raynaud's phenomenon. She is unusual in that the arthritis of that she remained perfectly well without treatment for 5 years, despite persistently abnormal serology. ???? usually involves small joints, but it is important to note 8mg/I (normal) Negative Positive (titre 1/80; IgG class) 80% (NR 0-30% binding) C-reactive protein Rheumatoid factor Antinuclear antibody dsDNA-binding activity Antibodies to extractable nuclear antigens NegativeExplanation / Answer
Answer:
The blanks are filled with the correct information below:
A 26-year-old woman presented with painful, stiff knees of 4 weeks duration. She had a 6-year history of Raynaud's phenomenon. On examination, she had bilateral effusions in both knee joints, but all other joints were normal. She had no skin lesions, muscle tenderness, proteinuria or fever. The results of relevant investigations are shown in Table C10.1. On the basis of these, a diagnosis of (Systemic lupus erythematosus "SLE") was made and the patient treated with aspirin for her painful knees. She improved over 4 weeks and then remained symptom-free for 5 years. During this time, her antinuclear antibody remained positive at 1/80, her DNA-binding activity varied from 40 to 80%, and her C3 and C4 levels were occasionally low. Later, she developed a bilateral, blotchy rash on her hands and thighs, consistent with active vasculitis. Her Raynaud's phenomenon concurrently became much worse. Following treatment with prednisolone, the skin manifestations gradually disappeared and the steroids were tailed off.
This patient presented with arthritis and Raynaud's phenomenon. She is unusual in that the arthritis of SLE usually involves small joints, but it is important to note that she remained perfectly well without treatment for 5 years, despite persistently abnormal serology.