Part 2. Gene to Protein: Modeling trans ation Hemoglobin Sequences Below are the

Question

Part 2. Gene to Protein: Modeling trans ation Hemoglobin Sequences Below are the coding strands of the normal and mutant (sickle cell) ?-globin sequences. The difference in the sequences is in bold. Normal allele 5 ATG GTG CAC CTG ACT CCT GAG GAG AAG...3 Mutant allele 5' ATG GTG CAC CTG ACT CCT GTG GAG AAG 3' scription and transl NORMAL ?-GLOBIN DNA mRNA TGA GGA CTC CTC. thrproglu glu MUTANT ?-GLOBIN DNA ...TGA GGA CAC CTO thrprovalglu Part 3: The most widely used blood test for sickle cell disease and trait is the hemoglobin on filter paper and the different hemoglobins travel at different speeds to the negative pole A blood sample is placed in an electric field

Explanation / Answer

Answer part 3. Haemoglobin electrophoresis.

This technique works on the principle of the gel electrophoresis, where different hemoglobins in our body migrate at different rates. Hemoglobin is an iron rich carrier protein that helps in the transportation of oxygen in our body. Mutation in a single base of DNA from C to A leads to sickle cell anemia, because there occurs change in the amino acid produced. The people infected with sickle cell anaemia are protected from malaria.

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