Why are there mice with patchy fur coloration during the creation of a knockout

Question

Why are there mice with patchy fur coloration during the creation of a knockout mouse? Choose best answer and please include your reasoning. 1-They are females exhibiting functional mosaicism due to random X inactivation 2-They are genetic mosaics created by Flp FRT site-specific recombination during the blastocyst step of development 3-They are genetic mosaics generated by injecting engineered cells into another blastocyst 4-The black patches are sensitive to a drug given to the mice to select for gene knockout

Explanation / Answer

3-They are genetic mosaics generated by injecting engineered cells into another blastocyst

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