Assume that you are given the task of testing for associationbetween genotypes a

Question

Assume that you are given the task of testing for associationbetween genotypes at a given locus (with two possible alleles a andA) and disease phenotype. The data consist of the following 300family trios (M,F,O): 80 families of the type (aa,aA,aA), 20families of the type (aa,aA,aa), 100 families of the type(aA,aA,AA), 60 families of the type (aA,aA,aA), 10 families of thetype (aA,aA,aa), 20 families of the type (aa,aa,aa), and 10families of the type (AA,AA,AA).

a)     Define the null and alternativehypotheses.

b)     Code all genotypes by using the numberof A alleles in the genotypes.

Explanation / Answer

There are total 300 families trios. A : (aa,aA,aA) type of families    :80 B : (aa,aA,aa) type offamilies      :20 C : (aA,aA,AA) type of families   :100 D : (aA,aA,aA) type of families   :60 E :(aA,aA,aa) type offamilies      :20 F : (aa,aa,aa) type offamilies        :10                         The null hypothesis is H0 : There is no significancedifferance between genotypes(A,B,C,D,E,F) at a given locusand disease       phenotype.              The alternative hypothesis is H1 : There is asignificance differance between genotype(A,B,C,D,E,F) ata given locus and      disease phenotype.  

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