In 1984, Macias-Flores et al. (Hum. Genet. 66:66-70) published the pedigree of a

Question

In 1984, Macias-Flores et al. (Hum. Genet. 66:66-70) published the pedigree of a family from Mexico with the sex-linked dominant trait known as congenital generalized hypertrichosis (CGH). The phenotype of CGH is a substantial increase in the number of hair follicles on the body, such that there is considerably more body hair on both males and females. The pedigree included an affected male who married a woman with a normal hair phenotype and they had 10 children, including 4 daughters and 6 sons. How many of this man's children do you expect to have the CGH phenotype? 0 4 9 14

Explanation / Answer

CGH is a dominant pattern X linked inheritance due to abnormalities in  Xq24-27.1 . In the above case since the man is affected and female is normal the chances of the male children being affected is zero as the male can pass the X chromosome only to daughters and not sons.All the female children are affected.

B.4

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