In 1984, Macias-Flores et al. (Hum. Genet. 66:66-70) published the pedigree of a
ID: 53342 • Letter: I
Question
In 1984, Macias-Flores et al. (Hum. Genet. 66:66-70) published the pedigree of a family from Mexico with the sex-linked dominant trait known as congenital generalized hypertrichosis (CGH). The phenotype of CGH is a substantial increase in the number of hair follicles on the body, such that there is considerably more body hair on both males and females. The pedigree included an affected male who married a woman with a normal hair phenotype and they had 10 children, including 4 daughters and 6 sons.
How many of this man’s children do you expect to have the CGH phenotype?
A. 0
B. 4
C. 7
D. 9
E. 14
Although CGH females have more hair than females who do not have the disorder, CGH females have less hair than CGH males, and the pattern of increased hair is often patchy. What genetic principle best explains the female phenotype?
A. Segregation
B. Independent assortment
C. Lyon hypothesis
D. Parental equivalence
E. Nondisjunction
Explanation / Answer
1. option B ,4 as daughters will be affected with CGH phenotype ,as it is X linked disease dominant disease .
2. option C lyon hypothesis