Please show your work. Package inserts for cefdinir capsules and oral suspension

Question

Please show your work. Package inserts for cefdinir capsules and oral suspension state that following oral administration, the bioavailability of cefdinir suspension is 120% relative to the capsules. The bioavailability of cefdinir capsules is 21% following the administration of a 300 mg dose and 15% following a 600 mg dose. o Calculate the bioavailability of cefdinir suspension o How much drug is absorbed following the administration of 300 mg and 600 mg tablets? Why does the bioavailability change with dose?

Explanation / Answer

-The amount of drug absorbed following the administration of 300 mg tablets is=(300*21/100)=63 mg

The amount of drug absorbed following the administration of 600 mg tablets is=(600*15/100)=90 mg

-Bioavailability of cefdinir suspension in 300 mg dose is=(120*63/100)/3=25.2%

Bioavailability of cefdinir suspension in 600 mg dose is=(120*90/100)/6=18%

-Bioavailability changes with dose because bioavailability depends on how rapidly and completely the active ingredient of drug gets absorbed in the gastrointestinal tract and the bloodstream. Too high or too low dose of a drug can lead to incomplete or partial absorption.

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