Patients with heart failure, diabetes, cancer, and lung disease who have various

Question

Patients with heart failure, diabetes, cancer, and lung disease who have various infections from gram negative organisms often receive aminoglycosides. One of the side effects of aminoglycosides is nephrotoxicity (possible damage to the kidney). A study was performed comparing the (rise in serum creatinine of at least 0.5 mg/dL) for the aminoglycosides gentamicin. The following results were obtained: Test the hypotheses that there is a significant relationship between gentamicin and nephrotoxicity using a chi-square test with alpha = 5%. What is the alternative hypothesis? a. There is no association between gentamicin and nephrotoxicity b. There is an association between gentamicin and nephrotoxicity c. Those who take gentamicin have greater serum creatinine levels d. Those who take gentamicin have lower serum creatinine levels What is the critical value? a. +1.96 b. +1.7959 c. +1.645 d. +3.84 What is the expected value of those who take gentamicin and have a rise in serum creatinine Round to two decimal places. a. 30.89 b. 23.67 c. 18.11 d. 97, 62 What is the expected value of those who take gentamicin and have no rise in serum creatinine? Round to two decimal places. a. 49.89 b. 74.45 c. 85.11 d. 32.23 What is the expected value of those who do not take gentamicin and have a rise in serum creatinine? Round to two decimal places. a. 23.67 b. 18.11 c. 30.89 d. 57.85 What is the expected value of those who do not take gentamicin and have no rise in creatinine? Round to two decimal places. a. 18.11 b. 97.62 c. 30.89 d. 49.89

Explanation / Answer

17. Correct Answer: Option (B)

18. Correct Answer: Option (D)

Critical X^2: 3.841456

19. Correct Answer: Option (A)

since

(116*49)/184 = 30.89

20.Correct Answer: Option (C)

since (116*135)/184 = 85.11

21 Correct Answer: Option (B)

since (68*49)/184 = 18.11

22.

Correct Answer: Option (D)

since (68*135)/184 = 49.89

Rise No Rise Total Gentamicin 34 82 116 No Gentamicin 15 53 68 Total 49 135 184

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