Hey so I\'m having some trouble with this homework question I was assigned. One
ID: 34922 • Letter: H
Question
Hey so I'm having some trouble with this homework question I was assigned.
One form of deafness called CMT is caused by the absence of a single amino acid in the middle of the PMP22 protein: everything else about the protein is normal. You look at the sequence of the PMP22 gene in a normal person and a person with CMT. When you are comparing the two sequences, you would expect to find that the person with CMT has:
Question 1 options:
An insertion
A deletion
A new termination codon
Either b) or c)
Any of the above is possible
So I'm thinking its a deletion, but wouldn't that shift the reading frame and make the rest of the protein abnormal? Unless its talking about deleting an entire amino acid instead of just one nucleotide. Also is there any chance a termination codon could work in this case?
A)An insertion
B)A deletion
C)A new termination codon
D)Either b) or c)
E)Any of the above is possible
Explanation / Answer
Answer is deletion (addition is also possible). It wouldn't shift the reading frame. And, the final protein remains the same so, there is no possibility of forming a new termination codon. Hope I am correct.