Please submit to Kelvin Chan on Monday, February 19, 2018. Credit will only be g

Question

Please submit to Kelvin Chan on Monday, February 19, 2018. Credit will only be given to assignments that have at least 3 out of 4 correct. During parent-teachers conference at Stony Creek Elementary, Ms. Katz tells 5-year-old Jane's parents that she has been day-dreaming a lot. When Jane's parents ask their child what seems to be the problem, Jane tells them that she does not daydream and always tries to listen attentively. However, she says that Ms. Katz sometimes speaks very quickly - so quickly like she jumps into the future and she missed what she said in between her jumps". Her parents take her to a pediatric clinic who then sends her to Dr. Wallgruth. Having left St. Slowendum Hospital for private practice, Dr. Wallgruth examines Jane. After a standard neurological exam, he orders an EEG. The EEG gives the following results in the bottom: (Hint: note that each column corresponds to 1 second, count the number of spikes in each column to give you frequency of discharge) (retrieved from UpToDate, 2018) What type of condition does Jane most likely have? A. Febrile seizures B. Attention-Deficit Hyperactivity Disorder (ADHD) C. Absence seizures D. Tonic-clonic seizures E. Simple partial seizures 1. 2. Which of the following drugs is most appropriate to give for Jane's condition (recall the anatomical basis of the type of seizures Jane displays)? A. Diazepam, a positive allosteric modulator of GABAA B. Phenytoin, a blocker of voltage-gated Na' channels C. Valproic Acid, increases GABA in the brain and inactivates voltage-gated Na' channels D. Ethosuximide, an inhibitor of thalamic Ca2 channels E. Levetiracetam, an inhibitor of presynaptic voltage-gated Ca channels 3. When adding phenytoin (again, blocks voltage-gated Na channels) to pyramidal cells, what happens to the Nernst potential of Na"? A. Increases B. No Change C. Decreases D. Constantly in flux since the Na"/K' ATPase is affected Dr. Wallgruth decides that medicine is stupid, and he should switch careers into basic science. For his first project pro Neurological Disorders and Stroke (NI resolution techniques to examine ion channel function in disease. What lab techniques Wallgruth focus on to give him the best chance at being a funded investigator? A. Electroencephalogram (EEG) B. Functional MRI (TMRI) C. Field electrode recordings D. Patch-clamp recordings E. Electron microscopy (EM) 4. posal, he wants to develop a model for Jane's disease. On the National Institutes of INDS) website, he sees that the funding agency requests high spatial should Dr

Explanation / Answer

1.The condition that Jane most likely has is ABSENCE Of SEIZURES.A seizure is nothing but a disorder because the nerve cell activity in the brain is affected when phenytoin is added to the pyramidal cells.

4.the doctor should use EEG to give him the best chance of being a funded investigator

2.VAIPROIC ACID , INCREASES GABA IN THE BRAIN AND inactivates voltage gated sodium channels is the most appropriate drug to give for Jane's condition.

3.the Nernst potential of sodium ions is DECREASED when

Phenytoin is added to the pyrimdal cells.

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