Please choose the best of the 5 options in each Part, and explain why. Part A. D

Question

Please choose the best of the 5 options in each Part, and explain why.

Part A. Dysferlin

a) migrates to the site of membrane rupture in response to Ca2+ influx into the cell.

b) migrates to the site of membrane rupture in response to oxidant influx into the cell.

c) physically couples the most peripheral myofibrils in a muscle cell to the sarcolemma.

d) both (a) and (b) are correct.

e) None are correct.

Part B. How would sarcolemmal repair (S.Rep) in response to membrane wounding be altered in a muscle cell expressing mutant MG53 where Cys313 was changed to Ser?

a) S.Rep would be unaffected.

b) S.Rep would be greatly accelerated.

c) S.Rep would be abrogated.

d) The sarcolemma can’t be wounded in the Cys313Ser mutant muscle cells.

Part C. Regarding the development of therapies for Duchenne muscular dystrophy (DMD), scientists are attempting all of the following except :

a) intensive exercises like running.

b) to substitute for the protein missing in DMD with a surrogate protein.

c) to repair the mRNA defect caused by some mutations in the DMD gene.

d) dietary supplements like beet juice or green tea extract.

e) All of the above.

Explanation / Answer

Part A

d)both a and b are correct

Dysferlin migrate to the site of membrane rupture in response to Ca2+ and oxidant influx into the cell.

Part B

A) sarcolemmal would be unaffected as dysferlin plays a major role

Part C

A) intensive exercises like running.

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