Please choose the best option for each part: Part A. Which one of the following
ID: 3511327 • Letter: P
Question
Please choose the best option for each part:
Part A. Which one of the following statements concerning disorders of muscle metabolism is incorrect?
a. Mutations in animals can spread rapidly because of line breeding to prolific males, while the human genetic disorders typically affect fewer individuals (as a percent of the population).
b. The low rate of metabolism and ATP consumption in muscle and nerve makes effects of mitochondrial myopathies less observable in these tissues.
c. Glycogen storage diseases resulting from mutations in glycolytic and glycogen pathway genes typically cause accumulation of abnormal glycogen and/or exercise intolerance.
d. Lipid storage myopathies can result from deficiencies in enzymes of -oxidation and lead to the accumulation of triglyceride droplets in muscle fibers.
Part B. To inhibit pathological Ca2+ leak through RyR1 or RyR2 (e.g., as in malignant hyperthermia or heart failure), one might use this pharmacological agent:
a) caffeine
b) ryanodine
c) dantrolene
d) propofol
Part C. In the SERCA enzymatic cycle, this conformation releases Ca2+ inside the sarcoplasmic reticulum:
a) E1
b) E1~P
c) E2-P
d) E2
e) E1-P
Explanation / Answer
1- d,in lipid storage disease,not only triglycerides but also VLDL and chylomicrons also are accumulated and not only in muscles,they are accumulated in the entire body
2-dantrolene sodium is used in the treatment of malignant hyperthermia
3-confirmational change in E2-P releases ca in SR