Please choose the best option for each part and explain why it is correct: Part
ID: 3519086 • Letter: P
Question
Please choose the best option for each part and explain why it is correct:
Part 1: What is one of the required properties for a myogenic progenitor population to be used for the treatment of muscular dystrophies?
a. Ability to form teratomas
b. Uncontrolled proliferation after transplantation
c. Ability to form healthy functional muscle fibers
d. Ability to generate multiple cell types upon transplantation
e. Limited migratory ability
Part 2: What is one BROAD advantage of pluripotent stem cells over adult stem cells?
a. Ability to form teratomas
b. Uncontrolled proliferation after transplantation (in vivo)
c. Ability to form healthy functional muscle fibers
d. Ability to generate multiple cell types upon transplantation
e. Unlimited proliferation ability in the Petri dish (in vitro)
Part 3: What is one disadvantage of pluripotent stem cells over adult stem cells?
a. Ability to form teratomas
b. Low frequency and inability to be expanded in vitro
c. Ability to form healthy functional muscle fibers
d. Ability to repopulate the satellite cell pool
e. Unlimited proliferation ability in the Petri dish (in vitro)
Explanation / Answer
Answer 1. Answer will be option C that is ability to form healthy functional muscle fibers. Muscular dystrophy is the type of disease in which there is non development or degeneration of the developed muscles occurs. This is due to defect in gene. Myogenic progenitor cells can be differentiated in to muscle cells to replace the defected or degenerated muscles fibers.
Answer 2. Answer will be option D that is ability to generate multiple cell types upon transplantation. Pluripotent stem cells are that type of which can be differentiated in to any type of cell when transplanted in to the body. These are utilised in the different diseases caused due genetic defects and diseases present since birth. These are utilised mainly in blood cancers to regenerate blood cells.
Answer 3. Answer will be option B that is low frequency and inability to be expanded in vitro. The information about pluripotent stem cells are described in the answer 2.