Part B answer: Assume that 2.5 ATPs are generated per NADH and 1.5 ATPs per FADH

Question

Part B answer:

Assume that 2.5 ATPs are generated per NADH and 1.5 ATPs per FADH2. What is the total number of ATPs generated from 11 acetyl-SCoA molecules?

Express your answer as an integer.

110 ATP

Part C answer:

Assume that 2.5 ATPs are generated per NADH and 1.5 ATPs per FADH2. How many ATPs are generated from the FADH2 and NADH molecules from each repetition of the Beta-oxidation pathway?

Express your answer as an integer.

4

Activation of the fatty acid (converting it to fatty acyl-SCoA) requires the expenditure of 2 ATPs. Use your answers from parts B and C to calculate the total number of ATPs generated from the metabolism of a saturated fatty acid with 22 carbon atoms including both the citric acid cycle and the Beta-oxidation pathway as well as the initial ATP required to produce the acyl-SCoA molecule that starts the process.

4

Explanation / Answer

Part B

In terms of ATP, the yielding depends on the kind of yielding that is used for reduced cofactors:

If it is assumed that 2.5 ATPs are generated per NADH and 1.5 ATPs per FADH2,

11 acetyl CoA*10 ATP/Acetyl CoA in the Krebs cycle

=11*10

=110 ATP

Part C

Each repetition of the beta-oxidation pathway produces one NADH and one FADH2 molecules. So, each NADH gives rise to 2.5 ATP, and each FADH2 gives rise to 1.5 ATP. So, the total number of ATP produced are 2.5+1.5=4 ATPs.

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