Please answer the following 4 questions, there may be more than one answer for e
ID: 48575 • Letter: P
Question
Please answer the following 4 questions, there may be more than one answer for each question:
Select all statements that are true:
[ ] A single protein can have only one motif.
[ ] A given protein can consist of only one domain.
[ ] Hydrophobic interactions primarily drive tertiary structure folding.
[ ] Hydrogen bonding primarily drives secondary structure folding.
Mark all true statements about turns and loops:
[ ] They are generally located in the interior of proteins.
[ ] They can interact with other proteins and the environment.
[ ] Loops are found only on sheets.
[ ] Loops exposed to an aqueous environment are usually composed of hydrophilic amino acids.
What is the primary force that drives protein folding into its tertiary structure?
[ ] Van der Waal interactions
[ ] Covalent bonds
[ ] Hydrogen bonds
[ ] Hydrophobic interactions
Which of the following statements is/are true:
[ ] Successive similarly charged residues (eg. Glu-Glu-Glu-Glu) destabilizes and -helix.
[ ] All -helices found in proteins are left-handed because left handed helices are energetically more favorable due to fewer steric clashes between side chains.
[ ] Steric clashes have no effect on formation and stability of -helices.
[ ] Pro residues greatly destabilize -helices.
Explanation / Answer
A single protein can have only one motif. False A given protein can consist of only one domain False Hydrophobic interactions primarily drive tertiary structure folding True Hydrogen bonding primarily drives secondary structure folding Turn and loops are generally located in the interior of proteins. False Turns and loops can interact with other proteins and the environment True Loops are found only on sheets False Loops exposed to an aqueous environment are usually composed of hydrophilic amino acids True primary forces that drives protein folding into its tertiary structure are vander walls interaction, hydrogen bonds and hydrophobic interactions. Successive similarly charged residues (eg. Glu-Glu-Glu-Glu) destabilizes and -helix. False All -helices found in proteins are left-handed because left handed helices are energetically more favorable due to fewer steric clashes between side chains False Steric clashes have no effect on formation and stability of -helices False Pro residues greatly destabilize -helices True