Picture below represents reversible binding of a ligand (\"L\") to a protein (\"
ID: 493167 • Letter: P
Question
Picture below represents reversible binding of a ligand ("L") to a protein ("P"). Which of the below statements is true? K_ a is the dissociation constant. k_ d is the association constant. At equilibrium, k_ a = k_ d At equilibrium, the forward and reverse reactions occur at the same rate. The equilibrium constant can only be determined if the values of k_ a and k_ d are known. According to the table below, which protein and ligand bind most strongly? avidin and biotin avidin and insulin calmodulin and nickel ion calmodulin and calcium ion calmodulin and biotin Which of the following descriptions of the induced fit model is false? It was proposed by Emil Fisher in 1894. Conformational changes may occur in the protein upon ligand binding. Conformational changes may occur in the ligand upon ligand binding. It allows for tighter protein-ligand interaction compared to the lock and key model. It allows for binding of different ligands.Explanation / Answer
(6)
(A) Avidin and Biotin, because in order to bind most strongly, the Kd value has to be minimum
(7)
(A) , because induced fit model was suggested by Daniel Koshland in 1958