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Picture below represents reversible binding of a ligand (\"L\") to a protein (\"

ID: 493443 • Letter: P

Question

Picture below represents reversible binding of a ligand ("L") to a protein ("P"). Which of the below statements is true? k_a is the dissociation constant. k_d is the association constant. At equilibrium, k_a = k_d At equilibrium, the forward and reverse reactions occur at the same rate. The equilibrium constant can only be determined if the values of k_a and k_d are known. According to the table below, which protein and ligand bind most strongly? avidin and biotin avidin and insulin calmodulin and nickel ion calmodulin and calcium ion calmodulin and biotin Which of the following descriptions of the induced fit model is false? It was proposed by Emil Fisher in 1894. Conformational changes may occur in the upon ligand binding. Conformational changes may occur in the ligand upon ligand binding. It allows for tighter protein-ligand interaction compared to the and key model. It allows for binding of different ligands.

Explanation / Answer

5. (C) At equilibrium the forward and reverse reactions occour at the same rate

(D) The equilibrium constant values can be determined if the values of Kd and Ka are known.