The native folded state of a protein a directly encoded in its amino acid sequen
ID: 497298 • Letter: T
Question
The native folded state of a protein a directly encoded in its amino acid sequence. Proteins typically adopt a fold that single lowest energy state for a particular protein, the primary sequence can take any number of paths to arrive at this sequence samples a subset of these conformations as it proceeds from a high free energy to a low free energy state. molecular chaperones can partially unfold proteins to allow them lo better sample the conformational landscape. We can amino acid sequence may take to achieve its final folded state.Explanation / Answer
1.- top cell / (light blue): fully undolfed proteins, since it will NOT fold, it must be in the middle, before conformations, i.e the center
bottom cells:
left side
2 folding intermediates, since thoseshow th multitude of funneling in the structure via intramolecular contact
center of bottom cells
3. native structure
right side cell:
4.
misfolded aggregates it shows the conforationmoving forward amorphous aggregates via intermlecularcntact
Note that
aggregate frmation can occur frm intermediates clustering durin new folding or via destabilisation