Hi I have a quick questions regarding the hallmarks of the cancer-2-insensitivit
ID: 504885 • Letter: H
Question
Hi I have a quick questions regarding the hallmarks of the cancer-2-insensitivity to antigrowing. I want to know what is the outline or overview of this second type of the hallmarks of cancer which is insensitivity of antigrowing. Please give me in outlines of the overview of this kind of hallmarks please Hi I have a quick questions regarding the hallmarks of the cancer-2-insensitivity to antigrowing. I want to know what is the outline or overview of this second type of the hallmarks of cancer which is insensitivity of antigrowing. Please give me in outlines of the overview of this kind of hallmarks please I have a quick questions regarding the hallmarks of the cancer-2-insensitivity to antigrowing. I want to know what is the outline or overview of this second type of the hallmarks of cancer which is insensitivity of antigrowing. Please give me in outlines of the overview of this kind of hallmarks pleaseExplanation / Answer
The Second Hallmark of Cancer is defined as "Insensitivity to Antigrowth Signals".
Second Hallmark of Cancer inhibit growth rather than promote growth. Antigrowth factors can therefore block cell growth by the two mechanisms mentioned above; cellular quiescence through G0 and the post-mitotic state. A cancer cell must therefore evade these signals if it is to continue dividing uncontrollably. During the G1/S Checkpoint, cells monitor their microenvironment to choose whether to continue in the cell cycle, enter G0 or enter a post-mitotic state. At the molecular level, nearly all antigrowth signals are funneled through a protein known as the Retinoblastoma protein. Therefore, Retinoblastoma is classified as a tumor suppressor protein. Indeed, it was the very first tumor suppressor protein to be discovered in 1971 through an elegant process of deduction and statistical analysis of rare eye cancers.